map directive to switch the root for matching subdomains
server { server_name mysite.tld ~^.+.mysite.tld$; map $host $files { default common; mysite.tld common; www.mysite.tld common; admin.mysite.tld admin; system.mysite.tld system; *.mysite.tld users; } root /var/www/mysite/$files; }